Developmental and Evolutionary Genetics Lab
The Lab in Brief
Note: The lab website is currently being overhauled and redone. For updates on lab members, articles, research directions, please see immediately below and reach out to Terence Capellini (tcapellini@fas.harvard.edu)
Harvard Undergraduates:
We are currently looking for Harvard undergrads to join the lab starting Fall 2025. Please email the PI, Dr. Terence Capellini (tcapellini@fas.harvard.edu) for more information.
Prospective Post-doctoral Trainees:
We are currently looking to hire one post-doctoral fellow starting late 2025 or early 2026. Please email the PI, Dr. Terence Capellini for more information, but see this link: https://academicpositions.harvard.edu/postings/15449
For Recent Papers: https://pubmed.ncbi.nlm.nih.gov/?term=capellini+td&sort=pubdate&page=1
The Laboratory and Nearby Resources:
We have a new state-of-the-art lab located in the Peabody Museum at Harvard University, which includes ~8-10 workstations for technicians, undergraduate and graduate students, post-doctoral fellows, and visiting scholars. Our space also contains separate rooms for Biohazard Level II cell culture, microscopy, bacterial incubation and centrifugation, gel imaging, and lab kitchen work. Each room contains the necessary molecular, cell, developmental, genetics, and imaging equipment for a fully functioning laboratory. My office is down the hall in the HEB department, which has numerous teaching classrooms, libraries, and conference rooms. More broadly, we have access to facilities within the Biolabs building next door. These facilities include: The Bauer Core, which owns multiple real-time PCR machines, bioanalyzers, luminometers, fluorometers, DNA sequencers, among a variety of other equipment; The Harvard Center for Biological Imaging, which contains cutting-edge Carl Zeiss microscopes; The Genome Modification Facility, with the ability to perform the DNA micro-injection and gene targeting techniques we use in the lab; and the VWR stock room providing immediate access to laboratory supplies. For our bioinformatics studies, we have computational support in Resource Computing, possessing 55,000 processors and >12PB of shared storage, one of the largest clusters in the Boston area. This center is integrated with the Bauer Core for effective processing of experimental data. We also have two mouse rooms located in the Harvard BRI facility adjacent to the Peabody, which is a modern animal facility for clean "pathogen-free" work.
We are an NIH and NSF funded laboratory:
NIH R01 (NIAMS): Molecular architecture of the human knee joint and pelvis at single cell resolution – 9/1/2022-8/31/2027
NIH R01 (NIAMS): Leveraging human musculoskeletal development to identify causal disease variants - 9/1/2025-8/31/2030.
NSF (Anthropology): Interrogating Positively Selected Introgressed Variants in Modern Human Genomes for Regulatory Functions – 10/01/2020-Present
Additional Funding from Harvard Dean's Competitive Award, Milton Fund; Impetus Fund